Chemical Products Acyclovir Material and Products

CAS No:59277-89-3
Formula:C8H11N5O3
Synonyms:Acyclovir Tablets
China Export:From 2018.11 to 2019.11, total export volume of Acyclovir from China was 112,377,052KG while total export value was $2,146,929,254. The biggest proportion of exporting volume in the last 12 months was 9.88% in 2019.03.

Chemical Products Acyclovir Description
Acyclovir, a molecule tailored to inactivate the thymidine kinase of the herpesvirus, is a guanosine analogue antiviral drug. It is a drug for HSV infection by GlaxoSmithKline.IC50 Value: 0.53-0.75 uM [3]Target: HSVin vitro: Acyclovir sensitivity was determined in a plaque-reduction assay in Vero cells. IC50 Values were consistently 2-3 fold lower in B2 compared with the H strain of Vero cells. HSV Type 2 strains were 2-10-fold less sensitive than Type 1 strains [2]. in vivo: two patient

Chemical Products Acyclovir Basic Attributes
CAS No：59277-89-3

Molecular Formula ：C8H11N5O3

Molecular Mass ：225.2

Exact Mass ：225.086182

PSA ：115 A^2

LogP ：-1.6

EINECS ：261-685-1

InChIKeys ：MKUXAQIIEYXACX-UHFFFAOYSA-N

H-bond Acceptor ：4

H-bond Donor ：3

RBN ：4

Chemical Products Acyclovir Characteristics
Appearance ：white powder

Density ：1.8±0.1 g/cm3

Melting Point ：256-257°C

Bolling Point ：595°C at 760 mmHg

Flash Point ：302.4±32.3 °C

Refractive Index ：1.762

Solubility ：soluble in 1M HCl at 50mg/ml. soluble in water at 0.7mg/ml. Also soluble in DMSO

Storage Condition ：−20°C

Vapor Pressure ：5.4X10-15 mm Hg at 25 deg C (est)

Stability ：Stable. Incompatible with strong oxidizing agents.

Chemical Products Acyclovir Safety Information
Hazard Class ：IRRITANT

HS Code ：2933990090

UN No. ：NONH for all modes of transport

WGK_Germany ：2

Risk Code ：36/37/38-40-20/21/22

Safety Instructions ：22-24/25-36-26-23

RTECS No. ：UP0791400

Dangerous Mark ：Xi,Xn

Storage ：Treasury is ventilated, low temperature and dry; stored separately from food materials

P Code ：P201, P202, P264, P270, P280, P281, P301+P312, P302+P352, P308+P313, P312, P322, P330, P363, P405, P501

Hazard Statements ：H302

Flammability ：Flammable; burning releases toxic nitrogen oxide fumes; drug side effects; allergic dermatitis, dreams, fantasy

Toxicity ：Subcutaneous-rat LD50: 620 mg/kg; peritoneal-rat LD50: 860 mg/kg

Toxicity Class ：moderately

Chemical Products Acyclovir Product Usage
Orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. AntiviralBroad-spectrum antiviral drugs, containing purine nucleus compounds, are converted into triphosphate compounds in the body, interfere with viral DNA polymerase, inhibit viral DNA replication and play an antiviral effect. It has a strong effect on the virus. It is used for the prevention and treatment of viral skin or mucous membrane infections, as well as hepatitis B, herpes simplex keratitis, varicella zoster virus infection, etc.

Chemical Products Acyclovir Material and Products
Material ：
Adenine, 9-[(2-Acetoxyethoxy)methyl]-N2-acetylguanine, 6-Hydroxypurine, Activated carbon, 1,3-Dioxolane, 1,4-DIACETOXYBUTANE, Methylamine methanol, 6-Methoxyguanine, Guanine, TRIMETHYLSILANE, P-Toluenesulfonic Acid, Sodium Nitrite